Cambridge Institute for Medical Research
Membrane Traffic, Cell Biology, Biochemistry, Microscopy
I’m a research associate at the University of Cambridge and I’m passionate about membrane trafficking. In other words, I try to understand how proteins travel through the cell.
The human body is composed of billions of cells. Each one of them is like a small factory that communicates constantly with other cells. Cells produce proteins, which are packaged into small bags, called vesicles, that travel between different cell compartments or towards the cell surface to be secreted. These vesicles have the difficult task of transporting cargo to the right place at the right time and dysregulation of this trafficking can lead to a lot of diseases. My research tries to understand the molecular mechanisms behind this complex vesicular transport.
Between 2007 and 2010, I completed my PhD in Bruno Antonny’s laboratory (University of Nice-Sophia Antipolis). Here I focused on the regulation of proteins important for endocytosis events at the plasma membrane. I dissected at the molecular level, with artificial membranes and purified proteins, the interplay between these proteins. Next, I joined for my first postdoc, the team of Peter Novick, whose work contributed to the Nobel prize of medicine 2013 awarded to Randy Schekman (University of California, San Diego). I acquired a high expertise in yeast genetics whilst studying the final stage of the secretory pathway. In 2016, I joined the team of Rob Arkowitz (University of Nice-Sophia Antipolis) for two years where I focused on the importance of membrane trafficking during filamentous growth of the human pathogen Candida albicans. Finally, in 2019, I started a third postdoc with David Gershlick at the CIMR (University of Cambridge). My research here aims to increase understanding of Golgi to plasma membrane trafficking in mammalian cells using a combination of biochemical techniques and super resolution microscopy on living cells.