Physiology, Development and Neuroscience
Tissue Mechanics, Developmental Biology, Axon Guidance, Biophysics, Neuroscience
I am interested in how neurons (a type of cell in the nervous system) know how to grow and ‘wire’ correctly during development.
Neurons send extend axons, a long wire-like projection, that grow across massive distances and highly defined paths to connect to specific targets. Mis-wiring of neurons can result in neurodevelopment conditions such as autism spectrum disorder and movement related issues, to name a few. Most studies of neurons have focused on how chemical signals guide axon navigation. I am studying how mechanical signals from the surrounding environment, also regulate the pathfinding decisions of these axons. In my project, I exploit various interdisciplinary tools to study the interplay between mechanical and chemical signalling during nervous system development.